Remove from wall and place framed print on a ﬂat surface.
Then use a lint-free cloth to clean your frame.
Using chemical glass cleaners is never a good idea as this can cause damage to the Acrylic and possibly discolor your frame.
It is suggested to use an acrylic cleaner or a mild detergent solution along with a soft cotton cloth.
Also please note that any glass cleaner containing ammonia can cause the acrylic to turn yellow.